9 Vitamins & Supplements That May Affect Your Liver and Kidneys If Misused

at those levels. The NIH notes that high doses of nicotinic acid taken over months or years can be hepatotoxic, meaning harmful to the liver, and very high intakes can cause liver damage.

Niacin from food is not the same risk as high-dose pills. The danger usually comes from large supplemental doses, especially extended-release or sustained-release forms used without medical supervision.

4. Vitamin C in Very High Doses

Vitamin C is water-soluble and important for immune function and collagen production, but very large doses are not harmless for everyone. The